Structure and in Vitro Biological Testing of Water-Based Ferrofluids Stabilized by Monocarboxylic Acids
| Autor: | Vasil M. Garamus, Artem V. Feoktystov, Ladislau Vekas, Birte Mucha, Regine Willumeit, Katrin Lamszus, Oana Marinica, Mikhail V. Avdeev, Rodica Turcu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Steric effects
Ferrofluid Molecular Structure Carboxylic Acids Myristic acid Surfaces and Interfaces In Vitro Techniques Neutron scattering Condensed Matter Physics Magnetization chemistry.chemical_compound Nuclear magnetic resonance Microscopy Electron Transmission chemistry Chemical engineering Transmission electron microscopy Electrochemistry Scattering Radiation Magnetic nanoparticles General Materials Science Spectroscopy Magnetite |
| Zdroj: | Langmuir. 26:8503-8509 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la904471f |
| Popis: | Water-based ferrofluids (magnetic fluids) with double-layer steric stabilization by short monocarboxylic acids (lauric and myristic acids) are considered to be a potential source of magnetic nanoparticles in brain cancer (glioblastoma) treatment. Structure characterization in the absence of an external magnetic field is performed, including transmission electron microscopy, magnetization analysis, and small-angle neutron scattering with contrast variation. It is shown that despite the good stability of the systems a significant part of the magnetite nanoparticles are in aggregates, whose inner structure depends on the stabilizer used. In particular, an incomplete coating of magnetite particles is concluded in the case of myristic acid stabilization. The ferrofluids keep their structure unchanged when added to the cancer cell medium. The intracellular accumulations of magnetite from the ferrofluids added to cancer cell cultures as well as its cytotoxicity with respect to human brain cells are investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|