Analytical formulas representing track-structure simulations on DNA damage induced by protons and light ions at radiotherapy-relevant energies
| Autor: | Markus Eidemüller, Pavel Kundrát, Andrea Ottolenghi, Janine Becker, Giorgio Baiocco, Werner Friedland |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medicine
chemistry.chemical_element Radiation Article 030218 nuclear medicine & medical imaging Ionizing radiation Ion 03 medical and health sciences Neon Computational biophysics 0302 clinical medicine Humans DNA Breaks Double-Stranded Linear Energy Transfer Irradiation lcsh:Science Physics Coupling Multidisciplinary Radiotherapy lcsh:R Computational physics chemistry Macroscopic scale 030220 oncology & carcinogenesis lcsh:Q Protons Monte Carlo Method Biological physics Level of detail DNA Damage |
| Zdroj: | Sci. Rep. 10:15775 (2020) Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| Popis: | Track structure based simulations valuably complement experimental research on biological effects of ionizing radiation. They provide information at the highest level of detail on initial DNA damage induced by diverse types of radiation. Simulations with the biophysical Monte Carlo code PARTRAC have been used for testing working hypotheses on radiation action mechanisms, for benchmarking other damage codes and as input for modelling subsequent biological processes. To facilitate such applications and in particular to enable extending the simulations to mixed radiation field conditions, we present analytical formulas that capture PARTRAC simulation results on DNA single- and double-strand breaks and their clusters induced in cells irradiated by ions ranging from hydrogen to neon at energies from 0.5 GeV/u down to their stopping. These functions offer a means by which radiation transport codes at the macroscopic scale could easily be extended to predict biological effects, exploiting a large database of results from micro-/nanoscale simulations, without having to deal with the coupling of spatial scales and running full track-structure calculations. |
| Databáze: | OpenAIRE |
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