An Aggressive Primary Orbital Natural Killer/T-Cell Lymphoma Case
| Autor: | José A. Buil, Anna Mozos, Sebastián Prieto, Silvana Novelli, Tizana Marchino, Xavier Graell, Justyna Szafranska, Núria Ibáñez |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Vincristine Lymphoma genetic structures Cyclophosphamide medicine.medical_treatment CHOP Gastroenterology Fatal Outcome Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Exophthalmos Eye Pain Humans Etoposide Aged Chemotherapy Ifosfamide business.industry General Medicine medicine.disease eye diseases Lymphoma Extranodal NK-T-Cell Ophthalmology Orbital Neoplasms Female Surgery Orbital cellulitis Tomography X-Ray Computed business medicine.drug |
| Zdroj: | OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0740-9303 |
| DOI: | 10.1097/iop.0b013e3182a65026 |
| Popis: | Natural killer/T-cell lymphoma (NKTCL) and its presentation with extranodal orbital involvement as a single lesion are extremely rare. The aim of this article was to describe the presentation, diagnosis, and systemic treatment of a primary orbital NKTCL. A 67-year-old Caucasian woman presented with left exophthalmos, pain, periorbital swelling, and limited extrinsic ocular motility. Orbital cellulitis was suspected, but finally orbital biopsy was performed due to no response to initial antibiotic and anti-inflammatory standard treatment. The pathologic diagnosis was NKTCL. Systemic evaluations were negative. CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy was initiated, but after 2 cycles of treatment, tumoral progression was observed. SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, etoposide) rescue chemotherapy was then administered. Lymphoma progression was inevitable. She died 10 months later. Although more nasal NKTCL cases have been described, the nonnasal primary orbital NKTCL is an uncommon neoplasm with high mortality rate, despite the recent use of more potent chemotherapy regimens. |
| Databáze: | OpenAIRE |
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