A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
| Autor: | Clarissa S. Craft, Kristann L. Magee, Madelyn R. Lorenz, Xiao Zhang, Zhaohua Wang, Erica L. Scheller, Charles A. Harris, Hero Robles |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Stromal cell Mouse QH301-705.5 Science Adipose tissue Bone Marrow Cells Mice Transgenic Biology Bone and Bones General Biochemistry Genetics and Molecular Biology Mice chemistry.chemical_compound Bone Marrow Adipocyte Adipocytes medicine Animals Biology (General) Progenitor cell bone marrow adipocyte Adipogenesis Osteoblasts adiponectin General Immunology and Microbiology Adiponectin General Neuroscience aging Age Factors Cell Differentiation Cell Biology progenitor cells General Medicine Hematopoiesis Cell biology Mice Inbred C57BL Haematopoiesis medicine.anatomical_structure Adipose Tissue chemistry Medicine Female Bone marrow metabolism Research Article |
| Zdroj: | eLife eLife, Vol 10 (2021) |
| ISSN: | 2050-084X |
| DOI: | 10.7554/elife.66275 |
| Popis: | Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic ‘fat-free’ mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease. |
| Databáze: | OpenAIRE |
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