Macrolide Therapy of Group A Streptococcal Pharyngitis: 10 Days of Macrolide Therapy (Clarithromycin) Is More Effective in Streptococcal Eradication than 5 Days (Azithromycin)
| Autor: | Edward L. Kaplan, W. Manfred Gooch, Gerard F. Notario, J. Carl Craft |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Streptococcus pyogenes medicine.drug_class Antibiotics Administration Oral Azithromycin medicine.disease_cause Drug Administration Schedule Macrolide Antibiotics Throat culture Clarithromycin Streptococcal Infections Internal medicine medicine Humans Child Antibacterial agent medicine.diagnostic_test business.industry Streptococcus Pharyngitis Middle Aged Anti-Bacterial Agents Surgery Treatment Outcome Infectious Diseases Female medicine.symptom business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 32:1798-1802 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/320745 |
| Popis: | We compared recommended doses of 2 oral macrolide antibiotics (10 days of clarithromycin, 5 days of azithromycin) for eradicating group A streptococci from the throats of individuals aged > or = 12 years with symptomatic pharyngitis and a positive throat culture. Patients received either clarithromycin (250 mg b.i.d. for 10 days [n=260]) or azythromycin (500 mg on day 1, followed by 250 mg q.d. for 4 days [n=265]). Follow-up throat cultures were obtained both at 13--19 days and at 28--38 days. We evaluated 392 patients (median age, 26 years; clarithromycin, 194 patients; azyithromycin, 198 patients). Ten days of clarithromycin therapy was more effective than 5 days of azithromycin therapy in eradicating the organism (91% [176/194] vs. 82% [162/198]; P=.012). More than 97% of all streptococcal isolates were macrolide-sensitive. Whether these bacteriologic eradication rates were the result of the 2 macrolides compared or were due to differences in duration of therapy could not be determined, but the statistically significant difference in eradication of group A streptococci does raise additional questions about shortened courses of macrolide therapy for this common infection. |
| Databáze: | OpenAIRE |
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