Mononuclear Phagocyte Activation Is Associated With the Immunopathology of Psoriasis
| Autor: | Mariana C. Costa, Camilla S. Paixão, Débora L. Viana, Bruno de O. Rocha, Maíra Saldanha, Lícia M. H. da Mota, Paulo R. L. Machado, Carla Pagliari, Maria de Fátima de Oliveira, Sergio Arruda, Edgar M. Carvalho, Lucas P. Carvalho |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine lcsh:Immunologic diseases. Allergy T-Lymphocytes T cell Immunology Lipopolysaccharide Receptors sCD163 Antigens Differentiation Myelomonocytic Receptors Cell Surface CCL2 Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Antigens CD Psoriasis Immunopathology Humans Immunology and Allergy Medicine Cells Cultured Aged Skin Original Research Aged 80 and over Phagocytes Chemokine CCL20 Tumor Necrosis Factor-alpha business.industry Mononuclear phagocyte system psoriasis Middle Aged medicine.disease sCD14 cytokines Up-Regulation Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Leukocytes Mononuclear CXCL9 Tumor necrosis factor alpha business lcsh:RC581-607 030215 immunology mononuclear phagocytes |
| Zdroj: | Frontiers in Immunology, Vol 11 (2020) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this disease is associated with genetic, environmental and immunological factors, especially unbalanced T cell activation and improper keratinocyte differentiation. Psoriatic lesion infiltrate is composed of monocytes and T cells, and most studies have focused on the participation of T cells in the pathogenesis of this disease. Here we investigated the contribution of mononuclear phagocytes in the immunopathology observed in psoriatic patients. Significant increases in the levels of TNF, IL-1β, CXCL9, as well as the soluble forms of CD14 and CD163, were observed within the lesions of psoriatic patients compared to skin biopsies obtained from healthy individuals. Moreover, we found an association between the levels of CCL2, a monocyte attractant chemokine, and disease severity. In conclusion, our findings suggest a potential role for mononuclear phagocytes in the pathogenesis of psoriasis. |
| Databáze: | OpenAIRE |
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