Disposition of radiolabelled suppositories in humans
| Autor: | Robert M. Beihn, Michael Jay, Larry J. Caldwell, Arthur R. Mlodozeniec, Frank H. DeLand, George A. Digenis |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Time Factors Pharmaceutical Science Rectum chemistry.chemical_element Technetium Tc 99m Medronate Suppository Scintigraphy Technetium digestive system Inferior vena cava Dosage form Route of administration Humans Medicine Radionuclide Imaging Triglycerides Pharmacology Diphosphonates medicine.diagnostic_test business.industry Suppositories medicine.anatomical_structure chemistry medicine.vein Rectal administration Anesthesia business Nuclear medicine |
| Zdroj: | Journal of Pharmacy and Pharmacology. 37:266-268 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1985.tb05058.x |
| Popis: | The disposition of Witepsol H 15 suppositories radiolabelled with [99m Tc] technetium hydroxymethyldiphosphonate was studied after rectal administration in volunteers. The migration of the radiolabel was monitored continuously by external scintigraphy. The resulting scintiphotos were superimposed on lower GI radiographs to determine the extent of spreading of the dosage form in the rectum. The dosage form migrated approximately 5−7 cm into the rectum in nearly all of the studies and was, in general, confined to the lower and middle regions of the rectum. Since the venous supply to the lower rectum leads primarily to the inferior vena cava, the data presented here indicate that the metabolism of drugs sensitive to the ‘first-pass’ effect may be partially avoided by their rectal administration. |
| Databáze: | OpenAIRE |
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