Cyclic AMP signal transduction in posttraumatic stress disorder
| Autor: | Richard P. Ebstein, Shestatsky M, Bernard Lerer, Shemesh Z, Greenberg D |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Blood Platelets medicine.medical_specialty Prostaglandin Adenylate kinase Stress Disorders Post-Traumatic chemistry.chemical_compound Chlorides Internal medicine Sodium fluoride Receptors Adrenergic beta medicine Cyclic AMP Aluminum Chloride Humans Platelet Lymphocytes Alprostadil Aluminum Compounds Forskolin Cell Membrane Colforsin Isoproterenol Middle Aged Adenosine Psychiatry and Mental health Endocrinology chemistry Signal transduction Cyclase activity medicine.drug Adenylyl Cyclases Aluminum |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0002-953X |
| Popis: | Cyclic adenosine 3',5'-monophosphate (cAMP) signal transduction was examined in lymphocytes and platelets obtained from patients with posttraumatic stress disorder. Intact lymphocytes from the posttraumatic patients (N = 10) showed significantly lower basal, isoproterenol-, and forskolin-stimulated cAMP levels than those from 10 healthy control subjects. In platelet membrane preparations, basal, forskolin-, aluminum chloride plus sodium fluoride-, and prostaglandin E1-stimulated adenylate cyclase activity levels were all significantly lower in the posttraumatic group than in the control group. The authors discuss the potential role of their findings as a biological marker for posttraumatic stress disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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