Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell

Autor: Jong Hak Won, John Rugis, Di Zhu, Shawn Means, James Sneyd, David I. Yule
Rok vydání: 2017
Předmět:
0301 basic medicine
Statistics and Probability
Saliva secretion
Acinar Cells
Inositol 1
4
5-Trisphosphate
Biology
Models
Biological
Article
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Acinus
Acinar cell
medicine
Animals
Humans
Inositol 1
4
5-Trisphosphate Receptors
Parotid Gland
Computer Simulation
Calcium Signaling
Saliva
Ion transporter
Calcium signaling
Ion Transport
General Immunology and Microbiology
Ryanodine receptor
Applied Mathematics
Ryanodine Receptor Calcium Release Channel
Inositol trisphosphate
General Medicine
Inositol trisphosphate receptor
030104 developmental biology
medicine.anatomical_structure
Biochemistry
chemistry
Modeling and Simulation
Biophysics
Calcium
General Agricultural and Biological Sciences
Algorithms
030217 neurology & neurosurgery
Zdroj: Journal of Theoretical Biology. 419:383-393
ISSN: 0022-5193
Popis: We construct a model of calcium waves in a three-dimensional anatomically accurate parotid acinar cell, constructed from experimental data. Gradients of inositol trisphosphate receptor (IPR) density are imposed, with the IPR density being greater closer to the lumen, which has a branched structure, and inositol trisphosphate (IP3) is produced only at the basal membrane. We show (1) that IP3 equilibrates so quickly across the cell that it can be assumed to be spatially homogeneous; (2) spatial separation of the sites of IP3 action and IP3 production does not preclude the formation of stable oscillatory Ca2+ waves. However, these waves are not waves in the mathematical sense of a traveling wave with fixed profile. They result instead from a time delay between the Ca2+ rise in the apical and basal regions; (3) the ryanodine receptors serve to reinforce the Ca2+ wave, but are not necessary for the wave to exist; (4) a spatially-independent model is not sufficient to study saliva secretion, although a one-dimensional model might be sufficient. Our results here form the first stages of the construction of a multiscale and multicellular model of saliva secretion in an entire acinus.
Databáze: OpenAIRE
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