Parallel Synthesis of Glycomimetic Libraries: Targeting a C-Type Lectin
| Autor: | David A. Mann, Laura L. Kiessling, Kathryn M. Johnson, Michael C. Schuster, William D. Thomas, Tonia J. Buchholz |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Biomimetic materials
Natural product biology Molecular Mimicry Organic Chemistry Lectin Mannose Shikimic Acid Shikimic acid Mannose-Binding Lectin Biochemistry chemistry.chemical_compound chemistry Biomimetic Materials C-type lectin Glycomimetic biology.protein Combinatorial Chemistry Techniques Lectins C-Type Physical and Theoretical Chemistry Mannan-binding lectin |
| Zdroj: | Organic Letters. 5:1407-1410 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of alpha-methyl mannopyranoside were identified. [reaction: see text] |
| Databáze: | OpenAIRE |
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