Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics
| Autor: | Lorena García-Hevia, Nuria Terán, Juan Gallo, Jessica Oliveira, Mónica L. Fanarraga, Iñigo Casafont, Manuel Bañobre-López |
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| Přispěvatelé: | Universidad de Cantabria |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Theranosis QH301-705.5 0206 medical engineering Biomedical Engineering 02 engineering and technology Article Biomaterials Magnetic resonance imaging In vivo medicine Doxorubicin Magnetic hyperthermia Biology (General) Materials of engineering and construction. Mechanics of materials Melanoma Nanocomposite medicine.diagnostic_test 021001 nanoscience & nanotechnology medicine.disease 020601 biomedical engineering Drug delivery systems TA401-492 Systemic administration Magnetic nanoparticles 0210 nano-technology human activities Biotechnology Biomedical engineering medicine.drug |
| Zdroj: | Bioact Mater . 2021 Jun 17;8:153-164 UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) Bioactive Materials Bioactive Materials, Vol 8, Iss, Pp 153-164 (2022) |
| Popis: | Nowadays, a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations. Thus, the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications. Herein, a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient, green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug (doxorubicin) into a natural nano-matrix. The theranostic performance of the final magnetic formulation was validated in vitro and in vivo, in melanoma tumors. The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy, together with MRI reporting capability. The application of an alternating magnetic field was found to play a dual role, (i) acting as an extra layer of control (remote, on-demand) over the chemotherapy release and (ii) inducing a local thermal ablation of tumor cells. This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes, which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy. Graphical abstract The systemic administration of magnetic hybrid lipid nanocomposites induces synergistic effects derived from the local thermal release of chemotherapeutics plus the direct effect of magnetic hyperthermia in vivo, while enabling T2-MRI monitoring. The dual-role of magnetic hyperthermia (on-demand controlled drug release, magnetic ablation) is key to enhance the therapeutic capability of the formulation.Image 1 Highlights • A biocompatible magnetic lipid nanoformulation was developed for cancer theranostics. • Its magnetic component enabled remote application of magnetic hyperthermia and non-invasive MRI. • Its systemic administration enhanced anti-tumoral activity while enabled MRI monitoring in vivo. • Magnetic hyperthermia synergized thermal release of chemotherapeutics with magnetic ablation. |
| Databáze: | OpenAIRE |
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