Impact of pro-domain stability of matrix metalloproteinase-8 on the outcome of sepsis

Autor:	Joseph N. McLaughlin, Sachin Yende, Robert E. Ferrell, Derek C. Angus, Lin Zhu, J Rella, Daniel R. Frederick, Ahmet Bakan, Lan Kong, Steven D. Shapiro, Ivet Bahar, Ata Murat Kaynar
Rok vydání:	2011
Předmět:	business.industry Neutrophil collagenase Inflammation Single-nucleotide polymorphism Matrix metalloproteinase Critical Care and Intensive Care Medicine MMP8 Bioinformatics medicine.disease Sepsis Zymogen activation Poster Presentation Immunology medicine Animal studies medicine.symptom business
Zdroj:	Critical Care
ISSN:	1364-8535
Popis:	Animal studies suggest matrix metalloproteinase-8 (MMP8) (neutrophil collagenase) impairs neutrophil (PMN) recruitment in inflammation; in humans, MMP8 has been associated with inflammation. We hypothesized that septic patients with single nucleotide polymorphisms (SNPs) in the MMP8 promoter region will have a survival advantage, and this advantage is due to differences in MMP8 enzymatic activity and not MMP8 levels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb05cdffa3faa4f517820cc57f79ff2 https://doi.org/10.1186/cc9698 Zobrazit plný text záznamu Full text from SpringerLink