Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex
| Autor: | Mark F. Bear, Kathleen K. A. Cho, Lena A. Khibnik |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Bear, Mark, Cho, Kathleen K., Khibnik, Lena A. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
genetic structures
Neuroscience(all) Action Potentials Visual system Neurotransmission Inhibitory postsynaptic potential Article Ocular dominance Mice Neuroplasticity medicine Animals Visual Pathways Visual Cortex Neuronal Plasticity General Neuroscience eye diseases Dominance Ocular Mice Inbred C57BL Monocular deprivation Visual cortex medicine.anatomical_structure Excitatory postsynaptic potential Sensory Deprivation Psychology SYSNEURO Neuroscience Photic Stimulation |
| Zdroj: | PubMed Central |
| Popis: | Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feedforward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission. National Institutes of Health (U.S.) |
| Databáze: | OpenAIRE |
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