The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests
| Autor: | Michal Safran, Amir Herman, Hila Hermon, Ziv Ben-Ari, Moshe Rubin, Keren Tsaraf, Irina Tachlytski, Yeruham Kleinbaum, Carmit Netanel, David Goitein, Sima Katsherginsky |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Liver Cirrhosis Male Sleeve gastrectomy medicine.medical_specialty medicine.medical_treatment Bariatric Surgery Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Liver Function Tests Fibrosis Non-alcoholic Fatty Liver Disease Diabetes mellitus Nonalcoholic fatty liver disease Weight Loss medicine Humans Prospective Studies Aged Adiponectin business.industry General Medicine Middle Aged medicine.disease Surgery Obesity Morbid 030104 developmental biology Treatment Outcome Liver Elasticity Imaging Techniques Feasibility Studies 030211 gastroenterology & hepatology Female Steatosis Steatohepatitis business Body mass index |
| Zdroj: | American journal of surgery. 222(1) |
| ISSN: | 1879-1883 |
| Popis: | Background Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures. |
| Databáze: | OpenAIRE |
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