Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
| Autor: | Moritz Gosling, Rene Rissel, Alexander Ziebart, Andreas Garcia-Bardon, Erik K. Hartmann, Robert Ruemmler, Jens Kamuf |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cardiac output Swine General Chemical Engineering Hemodynamics Blood withdrawal Shock Hemorrhagic General Biochemistry Genetics and Molecular Biology Microcirculation 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Internal medicine medicine Animals Oximetry Cardiac Output Cerebral oximetry 030304 developmental biology 0303 health sciences Spectroscopy Near-Infrared General Immunology and Microbiology business.industry General Neuroscience Hemodynamic Monitoring Brain Reference Standards Oxygen Shock (circulatory) Hemorrhagic shock Circulatory system Cardiology medicine.symptom business |
| Zdroj: | Journal of visualized experiments : JoVE. (147) |
| ISSN: | 1940-087X |
| Popis: | Hemorrhagic shock ranks among the main reasons for severe injury-related death. The loss of circulatory volume and oxygen carriers can lead to an insufficient oxygen supply and irreversible organ failure. The brain exerts only limited compensation capacities and is particularly at high risk of severe hypoxic damage.This article demonstrates the reproducible induction of life-threatening hemorrhagic shock in a porcine model by means of calculated blood withdrawal. We titrate shock induction guided by near-infrared spectroscopy and extended hemodynamic monitoring to display systemic circulatory failure, as well as cerebral microcirculatory oxygen depletion. In comparison to similar models that primarily focus on predefined removal volumes for shock induction, this approach highlights a titration by means of the resulting failure of macro- and microcirculation. |
| Databáze: | OpenAIRE |
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