Validation of simple measures of aortic distensibility based on standard 4-chamber cine CMR: a new approach for clinical studies
| Autor: | Marcus Kelm, Rolf Gebker, Christian Stehning, Volkmar Falk, Niky Ghorbani, Burkert Pieske, Nina Rank, Sebastian Kelle, Titus Kuehne, Lukas Stoiber, Tomas Lapinskas |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Cine MRI Magnetic Resonance Imaging Cine 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Cardiac magnetic resonance imaging Predictive Value of Tests medicine.artery Internal medicine medicine Humans Aortic distensibility Compliance Reproducibility 030212 general & internal medicine Aorta Retrospective Studies Observer Variation Original Paper medicine.diagnostic_test business.industry Reproducibility of Results General Medicine Middle Aged Cine mri Rapid assessment Sample size determination Descending aorta cardiovascular system Cardiology Aortic stiffness Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clinical Research in Cardiology Clinical Research in Cardiology, 109 (4) |
| ISSN: | 1861-0692 1861-0684 |
| Popis: | Objective Aortic distensibility (AD) represents a well-established parameter of aortic stiffness. It remains unclear, however, whether AD can be obtained with high reproducibility in standard 4-chamber cine CMR images of the descending aorta. This study investigated the intra- and inter-observer agreement of AD based on different angles of the aorta and provided a sample size calculation of AD for future trials. Methods Thirty-one patients underwent CMR. Angulation of the descending aorta was performed to obtain strictly transversal and orthogonal cross-sectional aortic areas. AD was obtained both area and diameter based. Results For area-based values, inter-observer agreement was highest for 4-chamber AD (ICC 0.97; 95% CI 0.93–99), followed by orthogonal AD (ICC 0.96; 95% CI 0.91–98) and transversal AD (ICC 0.93; 95% CI 0.80–97). For diameter-based values, agreement was also highest for 4-chamber AD (ICC 0.97; 95% CI 0.94–99), followed by orthogonal AD (ICC 0.96; 95% CI 0.92–98) and transversal AD (ICC 0.91; 95% CI 0.77–96). Bland–Altman plots confirmed a small variation among observers. Sample size calculation showed a sample size of 12 patients to detect a change in 4-chamber AD of 1 × 10−3 mmHg−1 with either the area or diameter approach. Conclusion AD measurements are highly reproducible and allow an accurate and rapid assessment of arterial compliance from standard 4-chamber cine CMR. Clinical Research in Cardiology, 109 (4) |
| Databáze: | OpenAIRE |
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