The Effects of Bergamot Polyphenolic Fraction, Cynara cardunculus, and Olea europea L. Extract on Doxorubicin-Induced Cardiotoxicity
| Autor: | Rocco Mollace, Vincenzo Mollace, Roberta Macrì, Francesca Bosco, Miriam Scicchitano, Micaela Gliozzi, Irene Bava, Federica Scarano, Francesca Oppedisano, Maria Caterina Zito, Jessica Maiuolo, Saverio Nucera, Cristina Carresi, Vincenzo Musolino, Stefano Ruga, Annamaria Tavernese |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Antioxidant Anthracycline medicine.medical_treatment Pharmacology doxorubicin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oleuropein medicine Doxorubicin TX341-641 chemistry.chemical_classification Bergamot Polyphenolic Fraction Cardiotoxicity Reactive oxygen species Nutrition and Dietetics ATF6 Nutrition. Foods and food supply nutraceutical support Endoplasmic reticulum Cynara cardunculus endoplasmic reticulum 030104 developmental biology chemistry rat embryonic cardiomyoblasts 030220 oncology & carcinogenesis oleuropein Food Science medicine.drug |
| Zdroj: | Nutrients, Vol 13, Iss 2158, p 2158 (2021) Nutrients Volume 13 Issue 7 |
| ISSN: | 2072-6643 |
| Popis: | Doxorubicin is an anthracycline that is commonly used as a chemotherapy drug due to its cytotoxic effects. The clinical use of doxorubicin is limited due to its known cardiotoxic effects. Treatment with anthracyclines causes heart failure in 15–17% of patients, resulting in mitochondrial dysfunction, the accumulation of reactive oxygen species, intracellular calcium dysregulation, the deterioration of the cardiomyocyte structure, and apoptotic cell death. Polyphenols have a wide range of beneficial properties, and particular importance is given to Bergamot Polyphenolic Fraction Oleuropein, one of the main polyphenolic compounds of olive oil and Cynara cardunculus extract. These natural compounds have particular beneficial characteristics, owing to their high polyphenol contents. Among these, their antioxidant and antoproliferative properties are the most important. The aim of this paper was to investigate the effects of these three plant derivatives using an in vitro model of cardiotoxicity induced by the treatment of rat embryonic cardiomyoblasts (H9c2) with doxorubicin. The biological mechanisms involved and the crosstalk existing between the mitochondria and the endoplasmic reticulum were examined. Bergamot Polyphenolic Fraction, Oleuropein, and Cynara cardunculus extract were able to decrease the damage induced by exposure to doxorubicin. In particular, these natural compounds were found to reduce cell mortality and oxidative damage, increase the lipid content, and decrease the concentration of calcium ions that escaped from the endoplasmic reticulum. In addition, the direct involvement of this cellular organelle was demonstrated by silencing the ATF6 arm of the Unfolded Protein Response, which was activated after treatment with doxorubicin. |
| Databáze: | OpenAIRE |
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