Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus
| Autor: | Federica del Genio, Sarah L. R'bibo, Timothy E. McGraw, Francesco Rubino, Madhu Mazumdar |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Enteroendocrine Cells Endocrinology Diabetes and Metabolism Bariatric Surgery Hyperlipidemias Enteroendocrine cell Bioinformatics Article Gastrointestinal Hormones Endocrinology Weight loss Internal medicine Diabetes mellitus Weight Loss Hyperlipidemia Humans Medicine Endocrine system Obesity Randomized Controlled Trials as Topic Gastrointestinal tract business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus medicine.disease Gastrointestinal Tract Treatment Outcome Diabetes Mellitus Type 2 Hyperglycemia Hypertension medicine.symptom Energy Intake business |
| Zdroj: | Nature Reviews Endocrinology. 6:102-109 |
| ISSN: | 1759-5037 1759-5029 |
| Popis: | Several conventional methods of bariatric surgery can induce long-term remission of type 2 diabetes mellitus (T2DM); novel gastrointestinal surgical procedures are reported to have similar effects. These procedures also dramatically improve other metabolic conditions, including hyperlipidemia and hypertension, in both obese and nonobese patients. Several studies have provided evidence that these metabolic effects are not simply the results of drastic weight loss and decreased caloric intake but might be attributable, in part, to endocrine changes resulting from surgical manipulation of the gastrointestinal tract. In this Review, we provide an overview of the clinical evidence that demonstrates the effects of such interventions-termed metabolic surgery-on T2DM and discuss the implications for future research. In light of the evidence presented here, we speculate that the gastrointestinal tract might have a role in the pathophysiology of T2DM and obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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