Infection induced inflammation is associated with erectile dysfunction in men with diabetes
| Autor: | Joost B. L. Hoekstra, R. J. A. Diepersloot, M. C. A. Blans, Jan-Dirk Banga, K.P. Bouter, Y. van der Graaf, Frank L.J. Visseren |
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| Přispěvatelé: | ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Human cytomegalovirus Clinical Biochemistry Congenital cytomegalovirus infection Antibodies Viral medicine.disease_cause Fibrinogen Biochemistry Diabetes Complications Erectile Dysfunction Diabetes mellitus medicine Humans Endothelial dysfunction Chlamydophila Infections business.industry General Medicine Odds ratio Chlamydophila pneumoniae Middle Aged medicine.disease Antibodies Bacterial Immunoglobulin A C-Reactive Protein Diabetes Mellitus Type 1 Erectile dysfunction Diabetes Mellitus Type 2 Immunoglobulin G Cytomegalovirus Infections Immunology business Biomarkers medicine.drug |
| Zdroj: | European journal of clinical investigation, 36(7), 497-502. Wiley-Blackwell |
| ISSN: | 0014-2972 |
| DOI: | 10.1111/j.1365-2362.2006.01653.x |
| Popis: | Background In diabetic patients with erectile dysfunction, endothelial dysfunction is a major underlying cause. Infection-induced inflammation may be associated with endothelial dysfunction. The goal of this study was to determine whether erectile dysfunction in patients with diabetes is associated with infections of Chlamydia pneumoniae or cytomegalovirus and/or with low-grade inflammation. Materials and methods Diabetic patients, 57 with and 33 without erectile dysfunction, were enrolled in a case–control study. Both groups of patients consists of type 1 and type 2 diabetics. Serum antibodies against cytomegalovirus and C. pneumoniae and markers of inflammation, including high-sensitivity C-reactive protein and fibrinogen, were measured. Results Adjusted odds ratios for erectile dysfunction in cytomegalovirus IgG, C. pneumoniae IgG and C. pneumoniae IgA seropositive men were 2·4 (95%CI; 1·0–6·0), 3·0 (95%CI; 1·2–8·1) and 1·8 (95%CI; 0·7–4·6), respectively. Odds ratios for the highest tertiles of high-sensitivity C-reactive protein and fibrinogen concentrations compared to the lowest tertile were 4·3 (95%CI; 1·4–13·1) and 6·6 (95%CI; 2·1–21·2), respectively. Conclusion Elevated high-sensitivity C-reactive protein or fibrinogen serum levels and infection with cytomegalovirus or C. pneumoniae were associated with erectile dysfunction in diabetes. The relation between cytomegalovirus and erectile dysfunction is markedly present in patients with elevated high-sensitivity C-reactive protein and fibrinogen levels, suggesting a modifying effect by the inflammation. |
| Databáze: | OpenAIRE |
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