Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan
| Autor: | Masaru Ido, Hajime Kamiya, Koki Taniguchi, Shigeru Suga, Masakazu Umemoto, Haruo Kuroki, Hiroaki Ito, Takashi Nakano, Kazunobu Ouchi, Kazutoyo Asada, Takaaki Tanaka |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Rotavirus 0301 basic medicine Microbiology (medical) Veterinary medicine medicine.medical_specialty Genotype Genotyping Techniques 030106 microbiology medicine.disease_cause Rotavirus Infections Feces 03 medical and health sciences 0302 clinical medicine Japan Epidemiology medicine Humans Prospective Studies 030212 general & internal medicine Molecular Epidemiology Reverse Transcriptase Polymerase Chain Reaction business.industry Infant Newborn Rotavirus Vaccines Infant General Medicine Vaccine introduction Virology Infectious Diseases Child Preschool Female Observational study business |
| Zdroj: | Japanese Journal of Infectious Diseases. 70:448-452 |
| ISSN: | 1884-2836 1344-6304 |
| DOI: | 10.7883/yoken.jjid.2016.286 |
| Popis: | In Japan, monovalent and pentavalent rotavirus (RV) vaccines were approved in 2011 and 2012, respectively. To monitor changes in the RV genotypes before and after vaccine introduction, we performed a prospective observational study among children (＜ 5 years) with gastroenteritis who tested RV-positive on antigen rapid tests. Stool samples were collected from 3 different sites in Japan: Tsu City, Mie Prefecture; Kurashiki City, Okayama Prefecture; and Isumi City, Chiba Prefecture. RV genotypes were determined using reverse transcription-polymerase chain reaction. In Tsu City, G3P[8] was dominant (61.0-77.1%) before vaccine introduction, but decreased after introduction. Meanwhile, in an inverse proportion to the decrease in G3P[8], G1P[8] increased until the 2013/14 season, when a sudden predominance of G2P[4] (100%) occurred. A similar trend was observed in Kurashiki City in terms of the extent of reduction in G3P[8] and the emergence of G2P[4]. In Isumi City, G1P[8] was dominant (70.3%) before vaccine introduction, and G9P[8] became predominant (83.3%) in the 2013/14 season. To determine whether the genotype changes are attributable to vaccines or natural epidemiological changes, ongoing continuous monitoring of the RV genotypes is required. |
| Databáze: | OpenAIRE |
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