Increase in Infant Measles Deaths During a Nationwide Measles Outbreak-Mongolia, 2015-2016
| Autor: | Chinbayar Tserendorj, Samdan Altanchimeg, Minal K. Patel, Buyanjargal Yadamsuren, Christopher T Lee, Oyungerel Munkhtogoo, Raydel Anderson, Christopher J. Gregory, Oyun-Erdene Tumurbaatar, José E. Hagan, LaShondra Berman, Sodbayar Demberelsuren, Nyamaa Gunregjav, Bolortuya Baatarkhuu, Chimedsuren Ochir, Darmaa Badarch, James L. Goodson, Baigalmaa Jantsansengee |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty 030106 microbiology Measles Article Disease Outbreaks Measles virus 03 medical and health sciences 0302 clinical medicine Risk Factors Case fatality rate medicine Immunology and Allergy Humans 030212 general & internal medicine Survival analysis biology business.industry Case-control study Infant Newborn Infant Odds ratio Mongolia medicine.disease biology.organism_classification Rash Survival Analysis Hospitals Pneumonia Infectious Diseases Case-Control Studies Female medicine.symptom business |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 |
| Popis: | Background Surveillance data from a large measles outbreak in Mongolia suggested increased case fatality ratio (CFR) in the second of 2 waves. To confirm the increase in CFR and identify risk factors for measles death, we enhanced mortality ascertainment and conducted a case-control study among infants hospitalized for measles. Methods We linked national vital records with surveillance data of clinically or laboratory-confirmed infant (aged Results Infant measles deaths increased from 3 among 2224 cases (CFR: 0.13%) in wave 1 to 113 among 4884 cases (CFR: 2.31%) in wave 2 (P < .001). Inpatient admission, 7–21 days before measles rash onset, for pneumonia or influenza (amOR: 4.5; CI, 2.6–8.0), but not other diagnoses, was significantly associated with death. Discussion Measles infection among children hospitalized with respiratory infections likely increased deaths due to measles during wave 2. Preventing measles virus nosocomial transmission likely decreases measles mortality. |
| Databáze: | OpenAIRE |
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