Diterpenoids and sesquiterpenoids from the twigs and leaves of Illicium majus
| Autor: | Wen-Jie Wang, Gui-Jie Zhang, Jing Qu, Hui Chen, Song Xu, Zhen-Feng Fang, Shuang-Gang Ma, Yang Liu, Shi-Shan Yu, Jian Bai |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Circular dichroism
China Magnetic Resonance Spectroscopy Stereochemistry Neutrophils Anti-Inflammatory Agents Pharmaceutical Science Illiciaceae Illicium Analytical Chemistry chemistry.chemical_compound Inhibitory Concentration 50 Cell Line Tumor Drug Discovery Organometallic Compounds Moiety Organic chemistry Animals Humans Abietane Pharmacology Plants Medicinal biology Molecular Structure Plant Stems Circular Dichroism Organic Chemistry Absolute configuration Stereoisomerism Dimolybdenum tetraacetate biology.organism_classification Rats Plant Leaves Complementary and alternative medicine chemistry Illicium majus Abietanes Molecular Medicine Diterpenes Sesquiterpenes |
| Zdroj: | Planta medica. 79(2) |
| ISSN: | 1439-0221 |
| Popis: | Four new abietane diterpenes ( 1 – 4 ) and two new cycloparvifloralone-type sesquiterpenoids ( 5 – 6 ) have been isolated from the twigs and leaves of Illicium majus , together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzkeʼs method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC 50 value of 0.26 ± 0.03 µM, while compounds 10, 11 , and 13 showed good anti-inflammatory activities with IC 50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM. |
| Databáze: | OpenAIRE |
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