Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosis
| Autor: | Ana S. Yamagata, Elisa Brietzke, Rodrigo B. Mansur, Graccielle R. Cunha, Rodrigo A. Bressan, Lucas B. Rizzo, Cinthia Higuchi, André Zugman, Pawan Kumar Maurya, Elson Asevedo, Maiara Zeni-Graiff, Ary Gadelha, Pedro Mario Pan, Sumit Sethi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Risk Oncology Psychosis medicine.medical_specialty Adolescent Global Assessment of Functioning Inflammation Disease Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Interview Psychological medicine Humans Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Interleukin medicine.disease 030227 psychiatry Peripheral Psychiatry and Mental health Cross-Sectional Studies Psychotic Disorders Schizophrenia Cytokines Female Tumor necrosis factor alpha medicine.symptom Psychology Biomarkers 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Schizophrenia Research. 176:191-195 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2016.06.031 |
| Popis: | Background Immuno-inflammatory imbalances have been documented in schizophrenia, but very little is known about the immunological changes prior to the onset of disease. Objective This work aimed to compare serum levels of pro- and anti-inflammatory cytokines in young subjects at ultra-high risk (UHR) of developing psychosis with age- and sex-matched healthy controls. Methods A total of 12 UHR and 16 age- and sex-matched healthy controls (HC) subjects were enrolled in this study. Clinical profile was assessed using the Comprehensive Assessment of At-Risk Mental States (CAARMS), Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or Kiddie-SADS-Present and Lifetime Version (K-SADS-PL), and Global Assessment of Functioning (GAF) scale. Serum interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, IFN-γ, and IL-17 were measured by flow cytometry using the Th1/Th2/Th17 cytometric bead array. Results Compared with the healthy control group, patients in UHR showed increased IL-6 levels (Z = − 2.370, p = 0.018) and decreased IL-17 levels in serum (Z = − 1.959, p = 0.050). Levels of IL-17 positively correlated to the values in GAF symptoms (rho = 0.632, p = 0.028). Conclusion Our results suggest that immunological imbalances could be present in the early stages of psychosis, including in at-risk stages. Future studies should replicate and expand these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect