The influence of patency of the vaginal process on the efficacy of hormonal treatment of cryptorchidism
| Autor: | M. Pombo Arias, R. Varela Cives, R. Tojo Sierra, A. Alonso Martin, A. Bautista Casasnovas |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Hernia Inguinal Chorionic Gonadotropin Human chorionic gonadotropin Cryptorchidism Testis Hydrocele medicine Humans Hernia Prospective Studies Child Prospective cohort study Gynecology Chemotherapy business.industry Incidence (epidemiology) Infant medicine.disease Radiography medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Female Gonadotropin Vaginal process business |
| Zdroj: | European Journal of Pediatrics. 155:932-936 |
| ISSN: | 1432-1076 0340-6199 |
| Popis: | To investigate the effects of patency of the vaginal process (processus vaginalis testis) on the efficacy of hormonal treatment of cryptorchidism, we carried out a blind, controlled, prospective study in which all patients underwent inguinal herniography. The sample comprised 310 boys with true cryptorchidism (244 unilateral, 66 bilateral) and without symptomatic hernia/ hydrocele or other pathologies. Patients age ranged from 8 months to 11 years 5 months. All patients were treated with human chorionic gonadotropin (twice-weekly intramuscular injections for 5 weeks; total dose 2500 IU for patients less than 1-year-old, 5000 IU for 1- to 6-year-olds, 10000 IU for 6- to 11-year-olds). Following treatment, 37% (139/376) of the testes descended. The incidence of descent was highest for testes initially in caudal positions. Considering only non patent (i.e., normal) vaginal processes, the incidence of testis descent was 49.5% (139/281); none of the 95 testes associated with a patent vaginal process descended in response to hormone treatment.Prior detection of patent vaginal process by inguinal herniography permits identification of a significant subset of patients for whom hormone treatment will be ineffective. Our data suggest that this predictive procedure is 100% reliable. |
| Databáze: | OpenAIRE |
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