Single-dose pharmacokinetics of daptomycin in children with suspected or proved gram-positive infections
| Autor: | Erica Fischer Hong, Susan M. Abdel-Rahman, David Benziger, Hasan S. Jafri, Richard F. Jacobs, Gregory L. Kearns |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Male Pediatrics medicine.medical_specialty Adolescent medicine.drug_class Metabolic Clearance Rate Gram-positive bacteria Antibiotics chemistry.chemical_compound Plasma Pharmacokinetics Daptomycin Internal medicine polycyclic compounds medicine Humans Child Chromatography High Pressure Liquid Gram-Positive Bacterial Infections Antibacterial agent biology business.industry Age Factors Lipopeptide biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification Anti-Bacterial Agents carbohydrates (lipids) Infectious Diseases Tolerability chemistry Child Preschool Pediatrics Perinatology and Child Health Injections Intravenous lipids (amino acids peptides and proteins) Female business medicine.drug Half-Life |
| Zdroj: | The Pediatric infectious disease journal. 27(4) |
| ISSN: | 0891-3668 |
| Popis: | New antimicrobials such as daptomycin fill a void in the growing need for antibiotics effective against resistant Gram-positive pathogens. Although the pharmacokinetics of daptomycin have been well characterized in adults, no studies have evaluated the pharmacokinetics and tolerability in a pediatric population.Twenty-five children (12-17 years, n = 8; 7-11 years, n = 8; 2-6 years, n = 9) were enrolled in this multicenter, open-label study. Daptomycin was administered as a single 4-mg/kg intravenous dose followed by repeated blood sampling for 24 hours. Daptomycin was quantitated from plasma using a validated high performance liquid chromatography method and pharmacokinetic variables determined using a model-dependent approach.Daptomycin systemic exposure decreased with decreasing age, reflecting more rapid rates of clearance in younger children. Total body exposure estimates in adolescents were approximately 1.7x those observed in children6 years of age (374.4 versus 215.3 microg*h/L), they were comparable to those observed in adult historic controls. Estimates of apparent elimination half-life averaged 6.7 hours in adolescents, 5.6 hours in children 7-11 years of age, and 5.3 hours in children6 years of age. One child had an adverse event (infusion site reaction) considered to be related to study drug.Systemic drug exposure after a single weight-adjusted daptomycin dose is reduced in younger children compared with adolescents and adults consequent to an apparent age-associated change in total plasma clearance. |
| Databáze: | OpenAIRE |
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