| Popis: |
Supplementary Figure 8: MLN4924 attenuates tumor growth inhibition by CBS9106 in human xenograft model. (A) SCID mice bearing HCT116 tumor xenografts are treated with vehicle (5% GA, p.o. + 10% HBC, s.c.), CBS9106 (250 mg/kg p.o. once per week), MLN4924 (10 or 60 mg/kg s.c. once per week), or combination of CBS9106 and MLN4924 (n = 6-8 mice/group) for two weeks. Data are expressed as the mean {plus minus} SEM. (B) Body weight change is measured during the treatment (means {plus minus} SEM). (C) Tumors are excised at 4 or 24 hours and the levels of Neddylated cullins and CRM1 are measured in the tumor lysates by western blot analysis (n = 3). Data are expressed as the mean {plus minus} SD. V:Vehicle. |
