Using the gut microbiota as a novel tool for examining colobine primate GI health
| Autor: | Rob Knight, Chia L. Tan, Duoying Cui, Se Jin Song, Hongxia Zhao, Jonathan B. Clayton, Gail Ackermann, Mark D. Schrenzel, Kefeng Niu, Vanessa L. Hale, Greg Humphrey, Jessica L. Metcalf, Josephine Braun, Katherine R. Amato |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Evolution Zoology Gut flora digestive system Microbiology 03 medical and health sciences Behavior and Systematics lcsh:QH540-549.5 biology.animal Captive breeding Captive Colobine Dysbiosis Gut microbiome Zoo Ecology Evolution Behavior and Systematics Ecology Nature and Landscape Conservation medicine 0501 psychology and cognitive sciences Primate 050102 behavioral science & comparative psychology Feces Colobinae biology 05 social sciences Foregut Akkermansia biology.organism_classification medicine.disease 030104 developmental biology lcsh:Ecology |
| Zdroj: | Global Ecology and Conservation, Vol 7, Iss C, Pp 225-237 (2016) |
| ISSN: | 2351-9894 |
| Popis: | Primates of the Colobinae subfamily are highly folivorous. They possess a sacculated foregut and are believed to rely on a specialized gut microbiota to extract sufficient energy from their hard-to-digest diet. Although many colobines are endangered and would benefit from captive breeding programs, maintaining healthy captive populations of colobines can be difficult since they commonly suffer from morbidity and mortality due to gastrointestinal (GI) distress of unknown cause. While there is speculation that this GI distress may be associated with a dysbiosis of the gut microbiota, no study has directly examined the role of the gut microbiota in colobine GI health. In this study, we used high-throughput sequencing to examine the gut microbiota of three genera of colobines housed at the San Diego Zoo: doucs ( Pygathrix) ( N = 7 ), colobus monkeys ( Colobus) ( N = 4 ), and langurs ( Trachypithecus) ( N = 5 ). Our data indicated that GI-healthy doucs, langurs, and colobus monkeys possess a distinct gut microbiota. In addition, GI-unhealthy doucs exhibited a different gut microbiota compared to GI-healthy individuals, including reduced relative abundances of anti-inflammatory Akkermansia. Finally, by comparing samples from wild and captive Asian colobines, we found that captive colobines generally exhibited higher relative abundances of potential pathogens such as Desulfovibrio and Methanobrevibacter compared to wild colobines, implying an increased risk of gut microbial dysbiosis. Together, these results suggest an association between the gut microbiota and GI illness of unknown cause in doucs. Further studies are necessary to corroborate these findings and determine cause-and-effect relationships. Additionally, we found minimal variation in the diversity and composition of the gut microbiota along the colobine GI tract, suggesting that fecal samples may be sufficient for describing the colobine gut microbiota. If these findings can be validated in wild individuals, it will facilitate the rapid expansion of colobine gut microbiome research. |
| Databáze: | OpenAIRE |
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