Carbonic Anhydrase IX is Not a Predictor of Outcomes in Non-Metastatic Clear Cell Renal Cell Carcinoma - A Digital Analysis of Tissue Microarray
Autor: | Marcelo Zerati, Katia R. M. Leite, Marcos F. Dall'Oglio, Cesar Camara Segre, Sabrina T. Reis, Miguel Srougi, José Pontes-Junior |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Oncology
Adult Male medicine.medical_specialty Pathology Time Factors Adolescent Urology lcsh:RC870-923 Statistics Nonparametric Young Adult Antigens Neoplasm Predictive Value of Tests Internal medicine medicine Carcinoma Biomarkers Tumor Humans Stage (cooking) Carbonic Anhydrase IX Child Carcinoma Renal Cell Aged Retrospective Studies Carbonic Anhydrases Aged 80 and over Tissue microarray business.industry Cancer Renal Cell Retrospective cohort study Middle Aged medicine.disease lcsh:Diseases of the genitourinary system. Urology Prognosis Immunohistochemistry Kidney Neoplasms Tumor Burden Clear cell renal cell carcinoma Tissue Array Analysis T-stage Female Neoplasm Grading business |
Zdroj: | International braz j urol v.39 n.4 2013 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology, Vol 39, Iss 4, Pp 484-492 (2013) International braz j urol, Volume: 39, Issue: 4, Pages: 484-492, Published: JUL 2013 |
Popis: | Introduction The knowledge about the molecular biology of clear cell renal cell carcinoma (ccRCC) is evolving, and Carbonic Anhydrase type IX (CA-IX) has emerged as a potential prognostic marker in this challenging disease. However, most of the literature about CA-IX on ccRCC comes from series on metastatic cancer, with a lack of series on non-metastatic cancer. The objective is to evaluate the expression of CA-IX in a cohort of non-metastatic ccRCC, correlating with 1) overall survival, and 2) with established prognostic parameters (T stage, tumor size, Fuhrman nuclear grade, microvascular invasion and peri-renal fat invasion). Materials and Methods This is a retrospective cohort study. We evaluated 95 patients with non-metastatic clear cell renal cell carcinoma, as to the expression of CA-IX. The analyzed parameters where: overall survival (OS), TNM stage, tumor size (TS), Fuhrman nuclear grade (FNG), microvascular invasion (MVI), peri-renal fat invasion (PFI). We utilized a custom built tissue microarray, and the immunoexpression was digitally quantified using the Photoshop® software. Results: Th e mean follow-up time was 7.9 years (range 1.9 to 19.5 years). The analysis of CA-IX expression against the selected prognostic parameters showed no correlation. The results are as follows: Overall survival (p = 0.790); T stage (p = 0.179); tumor size (p = 0.143); grouped Fuhrman nuclear grade (p = 0.598); microvascular invasion (p = 0.685), and peri-renal fat invasion (p = 0.104). Conclusion Carbonic anhydrase type IX expression does not correlate with overall survival and conventional prognostic parameters in non-metastatic clear cell renal cell carcinoma. |
Databáze: | OpenAIRE |
Externí odkaz: |