Myocardial adaptation and exercise performance in patients with pulmonary arterial hypertension assessed with patient-specific computer simulations
| Autor: | Niels Vejlstrup, Jørn Carlsen, Niels Thue Olsen, Christoffer Göransson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Patient-Specific Modeling Cardiac Catheterization medicine.medical_specialty Physiology Heart Ventricles Magnetic Resonance Imaging Cine Hemodynamics Adaptation (eye) Myocardial mechanics Predictive Value of Tests Physiology (medical) Internal medicine Exercise performance medicine Humans Familial Primary Pulmonary Hypertension In patient Rest (music) Exercise Tolerance business.industry Models Cardiovascular Middle Aged Patient specific Control subjects Adaptation Physiological Case-Control Studies Exercise Test Ventricular Function Right Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 321:H865-H880 |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | Myocardial function and exercise reserve are important determinants of outcome in pulmonary arterial hypertension (PAH) but are incompletely understood. For this study, we performed subject-specific computer simulations, based on invasive measurements and cardiac magnetic resonance imaging (CMR), to investigate whole circulation properties in PAH at rest and exercise and determinants of exercise reserve. CMR and right heart catheterization were performed in nine patients with idiopathic PAH, and CMR in 10 healthy controls. CMR during exercise was performed in seven patients with PAH. A full-circulation computer model was developed, and model parameters were optimized at the individual level. Patient-specific simulations were used to analyze the effect of right ventricular (RV) inotropic reserve on exercise performance. Simulations achieved a high consistency with observed data. RV contractile force was increased in patients with PAH (127.1 ± 28.7 kPa vs. 70.5 ± 14.5 kPa |
| Databáze: | OpenAIRE |
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