Time-resolved X-ray scattering studies of proteins
| Autor: | Valentyn Stadnytskyi, Hyun Sun Cho, Friedrich Schotte, Philip A. Anfinrud |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Range (particle radiation) Materials science Scattering Small-angle X-ray scattering X-Rays X-ray Proteins Article Computational physics 03 medical and health sciences 0302 clinical medicine X-Ray Diffraction Structural Biology Scattering Small Angle Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Curr Opin Struct Biol |
| ISSN: | 0959-440X |
| Popis: | Time-resolved small- and wide-angle X-ray scattering (SAXS/WAXS) studies of proteins in solution based on the pump-probe approach unveil structural information from intermediates over a broad range of length and time scales. In spite of the promise of this methodology, only a fraction of the wealth of information encoded in scattering data has been extracted in studies performed thus far. Here, we discuss the methodology, summarize results from recent time-resolved X-ray scattering studies, and examine the potential to extract additional information from these scattering curves. |
| Databáze: | OpenAIRE |
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