Downregulation of IL-17 and IFN-gamma in the optic nerve by beta-elemene in experimental autoimmune encephalomyelitis
| Autor: | Xiao-Guang Shi, Hongmei Yu, Rongwei Zhang, Ayong Tian, Lei Chen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Encephalomyelitis
Autoimmune Experimental Multiple Sclerosis Encephalomyelitis Immunology Interferon-gamma Mice Immune system medicine Immunology and Allergy Animals Humans Glycoproteins Pharmacology business.industry Plant Extracts Multiple sclerosis Experimental autoimmune encephalomyelitis Interleukin-17 Optic Nerve T helper cell medicine.disease Peptide Fragments Mice Inbred C57BL medicine.anatomical_structure Optic nerve Disease Progression Female Myelin-Oligodendrocyte Glycoprotein Immune disorder Interleukin 17 business Sesquiterpenes Phytotherapy |
| Zdroj: | International immunopharmacology. 10(7) |
| ISSN: | 1878-1705 |
| Popis: | Background β-elemene is a natural antitumor plant drug. Beneficial effects of β-elemene therapy have been demonstrated in some kinds of tumor clinically. Especially, it has been found to pass through the blood brain barrier easily. Other reports have indicated that immune disorder that appeared in some tumors usually can be seen in demyelinating diseases including multiple sclerosis and experimental autoimmune encephalomyelitis. However, no information regarding the effects of β-elemene therapy on the T helper cell subsets, Th1 or Th17 cells in experimental autoimmune encephalomyelitis has been found. Methods and findings We first determined morphologically that β-elemene therapy markedly suppressed the inflammation in experimental autoimmune encephalomyelitis optic nerve. We then determined the effect in vivo of β-elemene on Treg cells and Th17 and Th1 cells. We found that β-elemene treatment modulated immune balance in both the periphery and the inflamed optic nerve by promoting less downregulation in Treg cells, inhibiting Th17 and Th1 polarization. Conclusions Taken together, our finding reveals an important new locus where β-elemene induces substantial protection in experimental autoimmune encephalomyelitis optic nerve through signaling to several critical subsets of immune cells that reside in the peripheral and central nervous system. |
| Databáze: | OpenAIRE |
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