Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
| Autor: | Rosivaldo S. Borges, Taysa Ribeiro Schalcher, Marta Chagas Monteiro, José Luiz Fernandes Vieira, Claudio Guedes Salgado |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Adult Male Antioxidant lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 medicine.medical_treatment Biology medicine.disease_cause Nitric Oxide Antioxidants Nitric oxide Superoxide dismutase chemistry.chemical_compound Young Adult Leprosy medicine Humans Leprosy patients Mycobacterium leprae Glutathione Middle Aged medicine.disease biology.organism_classification Malondialdehyde Infectious Diseases chemistry Oxidative stress Case-Control Studies Immunology biology.protein Parasitology Female Oxidation-Reduction |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Vol 46, Iss 5, Pp 645-649 (2013) Revista da Sociedade Brasileira de Medicina Tropical, Volume: 46, Issue: 5, Pages: 645-649, Published: SEP 2013 |
| Popis: | Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients. |
| Databáze: | OpenAIRE |
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