Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants
| Autor: | Nan Yao, Hong-Yun Zeng, Chun-Yu Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Ceramide Programmed cell death Review Plant Science Computational biology lcsh:Plant culture Biology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound fumonisin B1 Fumonisin lcsh:SB1-1110 Gene Fumonisin B1 ceramides Sphingosine food and beverages plant growth Sphingolipid long chain bases cell death 030104 developmental biology chemistry sphingolipid Signal transduction 010606 plant biology & botany |
| Zdroj: | Frontiers in Plant Science Frontiers in Plant Science, Vol 11 (2020) |
| ISSN: | 1664-462X |
| DOI: | 10.3389/fpls.2020.600458 |
| Popis: | Fumonisin toxins are produced by Fusarium fungal pathogens. Fumonisins are structural analogs of sphingosine and potent inhibitors of ceramide synthases (CerSs); they disrupt sphingolipid metabolism and cause disease in plants and animals. Over the past three decades, researchers have used fumonisin B1 (FB1), the most common fumonisin, as a probe to investigate sphingolipid metabolism in yeast and animals. Although the physiological effects of FB1 in plants have yet to be investigated in detail, forward and reverse genetic approaches have revealed many genes involved in these processes. In this review, we discuss the intricate network of signaling pathways affected by FB1, including changes in sphingolipid metabolism and the effects of these changes, with a focus on our current understanding of the multiple effects of FB1 on plant cell death and plant growth. We analyze the major findings that highlight the connections between sphingolipid metabolism and FB1-induced signaling, and we point out where additional research is needed to fill the gaps in our understanding of FB1-induced signaling pathways in plants. |
| Databáze: | OpenAIRE |
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