EBV-associated, extranodal NK-cell lymphoma, nasal type of the breast, after heart transplantation
| Autor: | Hediya Y Draoua, Lawrence Tsao, Govind Bhagat, Mahesh Mansukhani, Bachir Alobeid |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Epstein-Barr Virus Infections medicine.medical_treatment CD3 Lymphoproliferative disorders Breast Neoplasms Biology Virus Pathology and Forensic Medicine Fatal Outcome hemic and lymphatic diseases medicine Humans Treatment Failure Heart transplantation Heart Failure CD43 Antibiotics Antineoplastic Nasal type medicine.disease Burkitt Lymphoma Lymphoma Transplantation Lymphoma Extranodal NK-T-Cell Doxorubicin Immunology biology.protein Heart Transplantation Female |
| Zdroj: | Modern Pathology. 17:125-130 |
| ISSN: | 1530-0285 0893-3952 |
| DOI: | 10.1038/sj.modpathol.3800040 |
| Popis: | Post-transplantation lymphoproliferative disorders (PTLDs) are predominantly Epstein–Barr virus (EBV)-associated B-cell lymphoproliferations. PTLDs of T-cell lineage are rare, mostly reported after renal transplantation and show less frequent association with EBV. NK-cell lymphomas after transplantation (NK-cell PTLDs) are very rare; only five cases are reported so far in the English literature, all developed after renal transplantation. We describe a case of EBV-associated, extranodal NK-cell lymphoma of nasal type, involving the breast in a cardiac allograft recipient 5 years after transplantation. The neoplastic cells are positive for CD2, cytoplasmic CD3, CD7, CD43, CD56, TIA-1 and p53; and negative for surface CD3 and CD57. Analysis of T-cell receptor beta and gamma genes fails to show clonal rearrangement. EBV studies show clonal episomal integration of EBV and latency II pattern (EBER-1+, LMP-1+, EBNA-1+, EBNA-2-). In conclusion, NK-cell PTLDs are rare complications that arise relatively late after solid organ transplantation, show strong association with EBV, and can follow an aggressive clinical course. To the best of our knowledge, we present the first reported case of NK-cell PTLD after cardiac transplantation and the unifying clinical and diagnostic features of NK-cell PTLDs occurring after solid organ transplantation. |
| Databáze: | OpenAIRE |
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