Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
| Autor: | Ivana Maria Fechine Sette, Josean Fechine Tavares, Marianna Vieira S. Castello-Branco, Margareth de Fátima Formiga Melo Diniz, Marcelo Sobral da Silva, Vicente Carlos de Oliveira Costa, Carolina Uchôa G. B. de Lima, Bárbara Viviana de Oliveira Santos, João Carlos Lima Rodrigues Pita, Cinthia S. Queiroga |
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| Jazyk: | portugalština |
| Rok vydání: | 2012 |
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| Zdroj: | Química Nova v.35 n.1 2012 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Volume: 35, Issue: 1, Pages: 138-142, Published: 2012 Química Nova, Vol 35, Iss 1, Pp 138-142 (2012) |
| Popis: | The phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named α-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol, β-caryophyllene and 4β,10α-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were determined by analysis of IR, MS and NMR data, as well as by comparison with literature data. The crude extract of R. leptopetala leaves demonstrated a weak cytotoxicity on sarcoma 180 cells with an IC50 of 512.3 µg/mL. However, the in vivo results showed that the extract exhibited a significant dose-dependent tumor growth reduction. |
| Databáze: | OpenAIRE |
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