R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
| Autor: | Gonzalo Garcia-Martin, Francisco Wandosell, Berta Alcover-Sanchez, Beatriz Cubelos |
|---|---|
| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España) |
| Rok vydání: | 2020 |
| Předmět: |
ERK1/2-MAPK
MAP Kinase Signaling System GTPase Review Biology Catalysis Inorganic Chemistry lcsh:Chemistry Myelin Phosphatidylinositol 3-Kinases Wnt/-catenin medicine Animals Humans Physical and Theoretical Chemistry Remyelination Neurodegeneration Molecular Biology lcsh:QH301-705.5 Wnt Signaling Pathway Spectroscopy PI3K/AKT/mTOR pathway Myelin Sheath Wnt/β-catenin TOR Serine-Threonine Kinases Organic Chemistry Wnt signaling pathway neurodegeneration R-Ras General Medicine medicine.disease Oligodendrocyte Computer Science Applications Crosstalk (biology) myelin medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 nervous system ras Proteins PI3K/Akt/mTOR Neuroscience oligodendrocyte Demyelinating Diseases |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 5911, p 5911 (2020) |
| Popis: | © 2020 by the authors. Myelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mechanisms can cause neurodegenerative myelin-associated pathologies. From oligodendrocyte progenitor cells to mature myelinating oligodendrocytes, myelination is a highly complex process that involves many elements of cellular signaling, yet many of the mechanisms that coordinate it, remain unknown. In this review, we will focus on the three major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin) and recent advances describing the crosstalk elements which help to regulate them. In addition, we will review the tight relation between Ras GTPases and myelination processes and discuss its potential as novel elements of crosstalk between the pathways. A better understanding of the crosstalk elements orchestrating myelination mechanisms is essential to identify new potential targets to mitigate neurodegeneration. This work was supported by the Spanish Ministry of Economy and Competitiveness, Grant: RTI2018-096303B-C33. |
| Databáze: | OpenAIRE |
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