Properties of a Cytotoxic Kidney Antibody Associated with Human Renal Transplantation
| Autor: | Nesrine Z. Baturay, Thomas L. Britten, Ernest V. Orsi, Norman Ende |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cytotoxicity
Immunologic Human leukocyte antigen Biology Kidney Antibodies medicine Animals Humans Transplantation Homologous Cytotoxic T cell Cytotoxic antibody Cells Cultured urogenital system Liver antibody Haplorhini General Medicine Kidney Transplantation Transplantation medicine.anatomical_structure Organ Specificity Immunology biology.protein Cancer research Adsorption Antibody Explant culture |
| Zdroj: | American Journal of Clinical Pathology. 71:543-548 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/71.5.543 |
| Popis: | A technic for demonstrating a complement-dependent cytotoxic response specific for human kidney cells was developed. Positive and negative sera from kidney-transplant recipients were subjected to several assay and adsorption procedures. The cytotoxic antibody reaction appeared to be specific against human kidney in tests with a variety of target cells. Manifestation of the typical cytotoxic effect depended on kidney explant target-cell surface changes following attachment, outgrowth, and dispersion of the first passage monolayer. A comparison of serum responses to lymphocytes and to kidney cells indicated that the cytotoxic response by human kidney cells is not related to the lymphocytotoxic antibodies associated with the HLA system. |
| Databáze: | OpenAIRE |
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