Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study
| Autor: | Prabhudas V. Patel, Dipak K. Patel, A. V. Ramachandran, Swati N. Desai, Ranjitsinh V. Devkar |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Murraya Pharmacology Toxicology Lipid peroxidation chemistry.chemical_compound Animals Super oxide dismutase biology Carbon Tetrachloride Poisoning Plant Extracts Polyphenols General Medicine Glutathione Ascorbic acid biology.organism_classification Rats Plant Leaves chemistry Biochemistry Catalase biology.protein Carbon tetrachloride Alkaline phosphatase Chemical and Drug Induced Liver Injury Food Science |
| Zdroj: | Food and Chemical Toxicology. 50:310-314 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2011.10.063 |
| Popis: | The present study investigates hepatoprotective effects of polyphenol rich Murraya koenigii L. (MK) hydro-ethanolic leaf extract in CCl(4) treated hepatotoxic rats. Plasma markers of hepatic damage, lipid peroxidation levels, enzymatic, and non-enzymatic antioxidants in liver and histopathological changes were investigated in control and treated rats. MK pretreated rats with different doses (200, 400 and 600mg/kg body weight) showed significant decrement in activity levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and bilirubin. Also, MK treated rats recorded a dose dependent increment in hepatic super oxide dismutase, catalase, reduced glutathione and ascorbic acid and, a decrement in lipid peroxidation. Microscopic evaluations of liver revealed CCl(4)-induced lesions and related toxic manifestations that were minimal in liver of rats pretreated with MK extract. These results demonstrate that hydro-ethanolic leaf extract of MK possesses hepatoprotective potentials. |
| Databáze: | OpenAIRE |
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