Effect of?-irradiated carbohydrates on isolated synaptic membranes
| Autor: | O. I. Shadyro, Sergei V. Konev, T. I. Lyskova, S. G. Samoilenko, Aksentsev Sl, G. V. Kaler, I. P. Edimecheva |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Free Radicals
Synaptic Membranes Biophysics Scavenger Metal Lipid peroxidation chemistry.chemical_compound Animals Irradiation Egtazic Acid Edetic Acid General Environmental Science Radiation Hydrogen Peroxide Carbohydrate Rats EGTA Glucose Membrane Biochemistry chemistry Gamma Rays visual_art Radiolysis visual_art.visual_art_medium Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Radiation and Environmental Biophysics. 32:345-355 |
| ISSN: | 1432-2099 0301-634X |
| DOI: | 10.1007/bf01225922 |
| Popis: | The effect of gamma-irradiated solutions of carbohydrates, mainly glucose, upon Na+, K(+)-ATPase and lipid peroxidation in rat brain synaptosomal membranes was studied. The membrane damage by irradiated glucose was enhanced in the presence of Fe2+ and was diminished when a free-radical scavenger (BHT) or metal chelators (EDTA, EGTA) were present. It is suggested that a key element in the free-radical membrane damage by irradiated carbohydrates is an Fe(2+)-complex of some species of the radiolysis products. Participation of radiotoxins of carbohydrate origin in radiobiological effects is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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