Onset of regular cannabis use and adult sleep duration: Genetic variation and the implications of a predictive relationship
| Autor: | Michael C. Stallings, Evan A. Winiger, John K. Hewitt, Spencer B. Huggett, Alexander S. Hatoum |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Sleep Wake Disorders Marijuana Abuse Time Factors Twins Toxicology Genetic correlation Article 03 medical and health sciences Young Adult 0302 clinical medicine Genetic variation Medicine Humans Pharmacology (medical) 030212 general & internal medicine Limited evidence Longitudinal Studies Depression (differential diagnoses) Retrospective Studies Pharmacology business.industry Genetic Variation Cannabis use Sleep in non-human animals Psychiatry and Mental health Female Age of onset business Sleep 030217 neurology & neurosurgery Demography Sleep duration Forecasting |
| Zdroj: | Drug Alcohol Depend |
| Popis: | Background Limited evidence suggests that early cannabis use is associated with sleep problems. Research is needed to understand the developmental impact of early regular cannabis use on later adult sleep duration. Methods In a sample of 1656 adult twins (56% female, Mean age = 25.79yrs), linear mixed effects models were used to analyze the influence of retrospectively assessed age of onset of regular cannabis use on adult sleep duration controlling for sex, depression, and current substance use. Twin analyses provided genetic and environmental variance estimates as well as insights into the association and potential casual relationships between these traits. Results Earlier age of onset for regular cannabis use was significantly associated with shorter adult sleep duration on both weekdays (β = −0.13, 95% CI = [−0.23, −0.04]) and weekends (β = −0.18, 95% CI = [−0.27, −0.08]). Additive genetics significantly contributed to the onset of regular cannabis use (a2 = 76%, 95% CI = [68, 85]) and adult weekend sleep duration (a2 = 20%, 95% CI = [11, 32]). We found evidence of a significant genetic correlation (rA = −0.31, 95% CI = [−0.41, −0.15]) between these two traits and our best fitting model was consistent with early onset of regular cannabis use causing shorter adult weekend sleep duration (β = −0.11, 95% CI = [−0.18, −0.03]). Conclusions Our results are consistent with the hypothesis that early onset of regular cannabis use may have a negative impact on adult sleep duration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|