Locoregional Recurrence in p16‐Positive Oropharyngeal Squamous Cell Carcinoma After TORS
Autor: | Bert W. O'Malley, Ryan M. Carey, Justin R. Shinn, Karthik Rajasekaran, Leila J. Mady, Robert M. Brody, David Shimunov, Roger B. Cohen, Jason G. Newman, Alexander Lin, Joshua Bauml, Devraj Basu, Gregory S. Weinstein, John N. Lukens, Steven B. Cannady |
---|---|
Rok vydání: | 2021 |
Předmět: |
Male
Natural Orifice Endoscopic Surgery Oncology medicine.medical_specialty medicine.medical_treatment Oropharynx Salvage therapy Alphapapillomavirus Lower risk Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Robotic Surgical Procedures Internal medicine Transoral robotic surgery medicine Adjuvant therapy Humans Oropharyngeal squamous cell carcinoma 030223 otorhinolaryngology Cyclin-Dependent Kinase Inhibitor p16 Aged Retrospective Studies Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections fungi Head and neck cancer Neck dissection Chemoradiotherapy Adjuvant Middle Aged medicine.disease Oropharyngeal Neoplasms Otorhinolaryngology 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Adjuvant |
Zdroj: | The Laryngoscope. 131 |
ISSN: | 1531-4995 0023-852X |
Popis: | OBJECTIVE To analyze the patterns, risk factors, and salvage outcomes for locoregional recurrences (LRR) after treatment with transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC). STUDY DESIGN Retrospective analysis of HPV+ OPSCC patients completing primary TORS, neck dissection, and NCCN-guideline-compliant adjuvant therapy at a single institution from 2007 to 2017. METHODS Features associated with LRR, detailed patterns of LRR, and outcomes of salvage therapy were analyzed. Disease-free survival (DFS) and overall survival (OS) were calculated for subgroups of patients receiving distinct adjuvant treatments. RESULTS Of 541 patients who completed guideline-indicated therapy, the estimated 5-year LRR rate was 4.5%. There were no identifiable clinical or pathologic features associated with LRR. Compared to patients not receiving adjuvant therapy, those who received indicated adjuvant radiation alone had a lower risk of LRR (HR 0.28, 95% CI [0.09-0.83], P = .023), but there was no difference in DFS (P = .21) and OS (P = .86) between adjuvant therapy groups. The 5-year OS for patients who developed LRR was 67.1% vs. 93.9% for those without LRR (P |
Databáze: | OpenAIRE |
Externí odkaz: |