BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain
| Autor: | Steven C. Cramer, Vincent Procaccio, Paul Rodriguez, Jeffrey A. Kleim, Stephanie A. McHughen, Laura Marchal Crespo, Erin D. Kleim |
|---|---|
| Přispěvatelé: | Biologie Neurovasculaire Intégrée (BNVI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Brain activity and meditation Image Processing [SDV]Life Sciences [q-bio] Neuropsychological Tests Brain mapping Functional Laterality Cohort Studies Computer-Assisted 0302 clinical medicine Methionine Oxygen/blood Image Processing Computer-Assisted genetics 610 Medicine & health Psychomotor Performance/physiology 0303 health sciences Brain Mapping medicine.diagnostic_test Brain-Derived Neurotrophic Factor/genetics fMRI Brain Experimental Psychology Valine Human brain Articles Magnetic Resonance Imaging cortex medicine.anatomical_structure Cognitive Sciences Female Psychology Motor learning Single Nucleotide/genetics Adult Adolescent Genotype Cognitive Neuroscience Movement Single-nucleotide polymorphism Polymorphism Single Nucleotide Methionine/genetics Fingers Functional Laterality/genetics 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult Motor system medicine Humans Learning Polymorphism 030304 developmental biology Brain-derived neurotrophic factor Analysis of Variance Brain/blood supply/physiology Brain-Derived Neurotrophic Factor Neurosciences Learning/physiology Valine/genetics Oxygen Fingers/physiology plasticity Movement/physiology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | McHughen, S. A.; Rodriguez, P. F.; Kleim, J. A.; Kleim, E. D.; Marchal Crespo, Laura; Procaccio, V.; Cramer, S. C. (2010). BDNF Val66Met Polymorphism Influences Motor System Function in the Human Brain. Cerebral cortex, 20(5), pp. 1254-1262. Oxford University Press 10.1093/cercor/bhp189 McHughen, Stephanie A; Rodriguez, Paul F; Kleim, Jeffrey A; Kleim, Erin D; Marchal Crespo, Laura; Procaccio, Vincent; et al.(2010). BDNF val66met polymorphism influences motor system function in the human brain.. Cerebral cortex (New York, N.Y. : 1991), 20(5), 1254-1262. doi: 10.1093/cercor/bhp189. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3wg6g781 Cerebral cortex (New York, N.Y. : 1991) Cerebral cortex (New York, N.Y. : 1991), 2010, 20 (5), pp.1254-1262. ⟨10.1093/cercor/bhp189⟩ |
| ISSN: | 1460-2199 |
| DOI: | 10.1093/cercor/bhp189 |
| Popis: | International audience; Brain-derived neurotrophic factor (BDNF) is important to brain functions such as plasticity and repair. A single nucleotide polymorphism for this growth factor, val(66)met, is common and associated with decreased activity-dependent BDNF release. The current study evaluated the effects of this polymorphism in relation to human brain motor system function, short-term plasticity, and learning. Functional magnetic resonance imaging (fMRI) scanning during right index finger movement (n = 24) identified activation in a broad sensorimotor network. However, subjects with the polymorphism showed smaller activation volume within several brain regions as compared with subjects without the polymorphism. Repeat fMRI after 25 min of right index finger training found that the 2 genotype groups modulated brain activation differently. In several brain regions, subjects with the polymorphism showed greater activation volume reduction, whereas subjects without the polymorphism showed greater activation volume expansion. On a driving-based motor learning task (independent cohort, n = 29), subjects with the polymorphism showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. The broader implications of these findings are considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|