Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guérin vaccine revaccinated in Chinese infants
| Autor: | Aiguo Ma, Xue-Gang Li, Xi Wang, Ming-Ci Zheng, Yong Li, Qiuzhen Wang, Ib C. Bygbjerg, Ying Zheng, Yongye Sun |
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| Jazyk: | angličtina |
| Předmět: |
Male
Vitamin Purified protein derivative China medicine.medical_specialty Tuberculosis Bacille Calmette-Guérin Immunization Secondary Scars Tuberculin Bacille Calmette Guerin Gastroenterology Cicatrix chemistry.chemical_compound Immune system Internal medicine Prevalence Vitamin D and neurology Humans Medicine Vitamin D Vitamin A Medicine(all) business.industry Age Factors Infant General Medicine medicine.disease Revaccination chemistry Dietary Supplements Immunology BCG Vaccine Female medicine.symptom business |
| Zdroj: | Asian Pacific Journal of Tropical Medicine. (2):130-135 |
| ISSN: | 1995-7645 |
| DOI: | 10.1016/S1995-7645(14)60008-0 |
| Popis: | ObjectiveTo investigate whether there is an association between diameter of bacille Calmette-Guérin (BCG) scars and effect of purified protein derivative (PPD) reaction and to determine whether vitamin A (VA) combined vitamin D (VD) supplementation influences the immune response to BCG revaccinated in Chinese infants.MethodsA cross-section and 3-month community-randomised trial was conducted. A total of 5 629 infants at 3, 6 and 12 months of age in Junan County of China were examined for BCG scar formation. Then, 597 revaccinated infants were randomly assigned to supplementation (n=307) and control (n=290) groups. The supplementation group were daily assigned to 1 500 IU VA and 500 IU VD for 3 months. Then all infants were subjected to skin test with PPD.ResultsThe diameter of BCG scars was positively correlated with diameter of skin indurations of PPD (r=0.17, P |
| Databáze: | OpenAIRE |
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