Supplementary Methods, Figures 1 - 6 from Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody

Autor: Keith L. Knutson, Marshall D. Behrens, James W. Krempski, Barath Shreeder, Kimberly R. Kalli, Adam D. Scheid, Purushottam Lamichhane, Lavakumar Karyampudi
Rok vydání: 2023
DOI: 10.1158/0008-5472.22398798.v1
Popis: PDF file - 418KB, Supplementary Methods and Results Fig. S1. In vitro blockade of PD-1 on TUBO cells does not inhibit cell growth. Fig. S2. CD4 T cells and CD4 Tregs in TUBO TILs. Fig. S3. Combination therapy enhances the antigen-specific function of tumor-infiltrating lymphocytes. Fig. S4. Antigen-specific production IL-5 and IL-4 by tumor-infiltrating CD8 T cells. Fig. S5. Combination therapy decreased the number of tumor-infiltrating myeloid derived suppressor cells (MDSCs). Fig S6. PD-1 expression on tumor DCs and splenic CD8 T cells in co-culture.
Databáze: OpenAIRE