Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1

Autor:	Jeffrey H. Tidwell, David J. Reynolds, Lee T. Schaller, George Andrew Freeman, Rob Ferris, Marty St. Clair, G B Roberts, Richard J. Hazen, Joseph H. Chan, Lawrence R. Boone, Kurt Weaver, Gina S. Lowell, Steven A. Short, Andrews Clarence Webster, Steve S. Gonzales, Katrina L. Creech, Jill R. Cowan, George W. Koszalka, Karen Rene Romines
Rok vydání:	2004
Předmět:	Anti-HIV Agents Mutant Crystallography X-Ray Virus Nucleoside Reverse Transcriptase Inhibitor Cell Line Benzophenones Inhibitory Concentration 50 Structure-Activity Relationship Pharmacokinetics Drug Discovery Drug Resistance Viral medicine Humans biology Reverse-transcriptase inhibitor Chemistry Wild type virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification Virology In vitro HIV Reverse Transcriptase Lentivirus Mutation HIV-1 Molecular Medicine Reverse Transcriptase Inhibitors medicine.drug Protein Binding
Zdroj:	Journal of medicinal chemistry. 47(5)
ISSN:	0022-2623
Popis:	GW4511, GW4751, and GW3011 showed IC50 values ≤2 nM against wild type HIV-1 and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e87ff312ea730b47c6c0b635ec73882 https://pubmed.ncbi.nlm.nih.gov/14971897 Zobrazit plný text záznamu