Surfactant–cobalt(III) complexes: The impact of hydrophobicity on interaction with HSA and DNA – insights from experimental and theoretical approach
| Autor: | Selvan Nehru, Gopal Sabapathi, Selvakumar Veeralakshmi, Ponnambalam Venuvanalingam, Sankaralingam Arunachalam |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Intercalation (chemistry) 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Hydrophobic effect Surface-Active Agents chemistry.chemical_compound Colloid and Surface Chemistry Pulmonary surfactant Organometallic Compounds medicine Animals Humans Physical and Theoretical Chemistry Serum Albumin Cobalt DNA Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Human serum albumin Ligand (biochemistry) 0104 chemical sciences Molecular Docking Simulation chemistry Diethylenetriamine Quantum Theory Cattle 0210 nano-technology Hydrophobic and Hydrophilic Interactions Biotechnology medicine.drug |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 153:85-94 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2017.02.013 |
| Popis: | To develop surfactant-based metallodrugs, it is very important to know about their hydrophobicity, micelle forming capacity, their interaction with biomacromolecules such as proteins and nucleic acids, and biological activities. Here, diethylenetriamine (dien) and tetradecylamine ligand (TA) based surfactant–cobalt(III) complexes with single chain domain, [Co(dien)(TA)Cl2]ClO4 (1) and double chain domain [Co(dien)(TA)2Cl](ClO4)2 (2) were chosen to study the effect of hydrophobicity on the interaction with human serum albumin and calf thymus DNA. The obtained results showed that (i) single chain surfactant–cobalt(III) complex (1) interact with HSA and DNA via electrostatic interaction and groove binding, respectively; (ii) double chain surfactant–cobalt(III) complex (2) interact with HSA and DNA via hydrophobic interaction and partial intercalation, respectively, due to the play of hydrophobicity by single and double chain domains. Further it is noted that, double chain surfactant–cobalt(III) complex interact strongly with HSA and DNA, compared single chain surfactant–cobalt(III) complex due to their more hydrophobicity nature. DFT and molecular docking studies offer insights into the mechanism and mode of binding towards the molecular target CT-DNA and HSA. Hence, the present findings will create new avenue towards the use of hydrophobic metallodrugs for various therapeutic applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect