Hard-To-Treat Idiopathic Refractory Autoimmune Haemolytic Anaemia with Reticulocytopenia
| Autor: | Tatiana Rodrigues, Ana Oliveira, Carla Matias, Marcelo Aveiro, Gisela Ferreira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Reticulocytosis lcsh:Medicine Azathioprine 030204 cardiovascular system & hematology Malaise 03 medical and health sciences 0302 clinical medicine reticulocytopenia Internal Medicine Medicine Reticulocytopenia haemolytic anaemia Epoetin beta azathioprine business.industry lcsh:R Articles Jaundice medicine.disease 030220 oncology & carcinogenesis Prednisolone Rituximab medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Case Reports in Internal Medicine (2020) Eur J Case Rep Intern Med |
| ISSN: | 2284-2594 |
| DOI: | 10.12890/2020_002112 |
| Popis: | Autoimmune haemolytic anaemia (AIHA) is an uncommon condition characterized by increased destruction of erythrocytes associated with reticulocytosis in the great majority of cases. We present the case of a 68-year-old woman with jaundice and malaise. Investigation revealed AIHA with reticulocytopenia. The patient failed to respond to prednisolone or to rituximab. Azathioprine and epoetin beta were subsequently started, the prednisolone dose was increased, and the patient began to respond after 1 month. In AIHA, reticulocytopenia is a very rare presentation and a sign of great severity and poor outcome. The scarcity of therapeutic options in refractory cases poses a major challenge for physicians. LEARNING POINTS: Autoimmune haemolytic anaemia is a rare disorder characterized by decompensated acquired haemolysis caused by the host’s immune system acting against its own red cell antigens. Concomitant presentation with reticulocytopenia is very rare and a sign of great severity and poor outcome. Treatment options in refractory cases still greatly rely on individual experience and expert opinion. |
| Databáze: | OpenAIRE |
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