Effect of Different Doses of Dexmedetomidine as Adjuvant in Bupivacaine -Induced Subarachnoid Block for Traumatized Lower Limb Orthopaedic Surgery: A Prospective, Double-Blinded and Randomized Controlled Study
| Autor: | Madhuri Ranjana Biswas, Anjan Das, Mainak Chandra, Parthojit Mandal, Susanta Halder, Tanuka Das, Debabrata Mandal, Souradeep Ray |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Clinical Biochemistry Analgesic lcsh:Medicine Hemodynamics law.invention Randomized controlled trial law Medicine Dexmedetomidine spinal anaesthesia (intrathecal Saline Bupivacaine business.industry lcsh:R dexmedetomidine General Medicine Anaesthesia Section hyperbaric bupivacaine Surgery Blunt trauma Anesthesia subarachnoid) Orthopedic surgery business medicine.drug |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 8, Iss 11, Pp GC01-GC06 (2014) |
| Popis: | Background and Aims: Improved pain management for blunt trauma to the lower extremity has shown to reduce morbidity, induce early ambulation and improve long-term outcomes. Dexmedetomidine; a selective α-2 agonist; has recently been used intrathecally in different doses to prolong spinal anaesthesia. We evaluated the effect of adding two different doses of dexmedetomidine to hyperbaric bupivacaine for spinal anaesthesia. The primary endpoints were the onset and duration of sensory, motor block and duration of analgesia. Materials and Methods: Eighty patients, (20-60yrs) posted for elective lower limb orthopedic surgery of traumatic origin under spinal anaesthesia were divided into 2 equal groups (Group D5 &D10) in a randomized, double-blind fashion. In this prospective parallel group study, group D5 (n=40) 3ml 0.5% hyperbaric bupivacaine+5µg dexmedetomidine in 0.5 ml of normal saline and group D10 (n=40) 3ml 0.5% bupivacaine+10µg dexmedetomidine in 0.5 ml of normal saline were administered intrathecally. Sensory and motor block onset times and block durations, time to first analgesic use, total analgesic need, postoperative VAS, hemodynamics and side effects were recorded for each patient. Results: Though with similar demographic profile in both groups, sensory and motor block in group D10(p0.05) without any appreciable side effects. Conclusion: Spinal dexmedetomidine increases the sensory, motor block duration and time to first analgesic use, and decreases analgesic consumption in a dose-dependent manner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|