Role of physical mechanisms in biological self-organization
| Autor: | Adrian Neagu, Richard Jamison, Karoly Jakab, Gabor Forgacs |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Self-organization
Tissue Engineering Computer science Quantitative Biology::Tissues and Organs Monte Carlo method Morphogenesis General Physics and Astronomy Biocompatible Materials CHO Cells Cell Communication Biocompatible material Models Biological Cell aggregation Quantitative Biology::Cell Behavior Extracellular Matrix Biological structure Cricetinae Spheroids Cellular Animals Computer Simulation Growth and Development Biological system Monte Carlo Method Function (biology) Cell Aggregation |
| Zdroj: | Physical review letters. 95(17) |
| ISSN: | 0031-9007 |
| Popis: | Organs form during morphogenesis, the process that gives rise to specialized biological structures of specific shape and function in early embryonic development. Morphogenesis is under strict genetic control, but shape evolution itself is a physical process. Here we report the results of experimental and modeling biophysical studies on in vitro biological structure formation. Experimentally, by controlling the interaction between cells and their embedding matrices, we were able to build living structures of definite geometry. The experimentally observed shape evolution was reproduced by Monte Carlo simulations, which also shed light on the biophysical basis of the process. Our work suggests a novel way to engineer biological structures of controlled shape. |
| Databáze: | OpenAIRE |
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