Lp-PLA2 activity and mass and CRP are associated with incident symptomatic peripheral arterial disease
| Autor: | Moncef Zarrouk, Stefan Acosta, Margaretha Persson, Olle Melander, Gunnar Engström, Shahab Fatemi, Anders Gottsäter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty lcsh:Medicine Gastroenterology Risk Assessment Article Cohort Studies 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Medicine Humans Cumulative incidence Longitudinal Studies Prospective Studies lcsh:Science Prospective cohort study Aged Proportional Hazards Models Multidisciplinary business.industry Proportional hazards model Incidence (epidemiology) Incidence lcsh:R Hazard ratio Middle Aged medicine.disease Atherosclerosis 030104 developmental biology C-Reactive Protein Cohort 1-Alkyl-2-acetylglycerophosphocholine Esterase Hypertension lcsh:Q Female business Body mass index 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31st, 2016. The diagnosis of PAD could be validated and confirmed in 98%. Cox regression was used to calculate hazard ratios (HR) per 1 standard deviation increment of each respective log transformed plasma biomarker. Cumulative incidence of PAD was 4.4% (men 5.9%, women 3.3%). Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, Lp-PLA2 activity (HR 1.33; 95% CI 1.17–1.52), Lp-PLA2 mass (HR 1.20; 95% CI 1.05–1.37) and CRP (HR 1.55; 95% CI 1.36–1.76) remained independently associated with incident PAD. The plasma biomarkers Lp-PLA2 activity and mass, and CRP were markers of PAD risk, implying that they might be useful biomarkers for subclinical atherosclerosis and atherosclerotic disease. |
| Databáze: | OpenAIRE |
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